(credits: Dr John Campbell) Ivermectin, a potential anticancer drug derived from an antiparasitic drug

https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC75051

Mechanisms of action

IVM induces different programmed cell death patterns in different tumor cells,

the main form of IVM induced programmed cell death is apoptosis.

Apoptosis

Programmed cell death

Autophagy

Lysosomal-dependent form of programmed cell death.

Pyroptosis

Inflammatory cell death induced by inflammasomes.

Kathleen T Ruddy, MD

https://twitter.com/bobanderso....n77/status/179700235

https://rumble.com/v4vk4pw-onc....ologist-kathleen-rud

https://twitter.com/DocRuddy

https://rumble.com/v4vk4pw-onc....ologist-kathleen-rud

Forms of cancer

Breast cancer

A malignant tumor produced by gene mutation in breast epithelial cells

Digestive system cancer

Gastric cancer is one of the most common malignant tumors worldwide.

Hepatocellular carcinoma is the fourth leading cause of cancer death worldwide.

Urinary system cancer

Renal cell carcinoma is a fatal malignant tumor of the urinary system derived from renal tubular epithelial cells.

Prostate cancer is a malignant tumor derived from prostate epithelial cells

Hematological cancer

Leukemia is a type of malignant clonal disease caused by abnormal hematopoietic stem cells

Reproductive system cancer

Cervical cancer is one of the most common gynecological malignancies

Ovarian cancer is a malignant cancer that lacks early clinical symptoms and has a poor therapeutic response.

Brain glioma

Glioma is the most common cerebral tumor

Glioblastoma, median survival time of 14-17 months

Respiratory system cancer

Nasopharyngeal carcinoma is a malignant tumor derived from epithelial cells of the nasopharyngeal mucosa.

Lung cancer has the highest morbidity and mortality among cancers

Melanoma

The most common malignant skin tumor with a high mortality rate.

Other papers

Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma

https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC72057

Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug

https://pubmed.ncbi.nlm.nih.gov/32474842/

Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer

https://www.nature.com/articles/s41523-021-00229-5

Abstract 2320: Ivermectin suppresses pancreatic cancer via mitochondria dysfunction

https://aacrjournals.org/cance....rres/article/82/12_S

Video reviews

https://www.youtube.com/watch?v=vCgNaOvICsk

https://www.youtube.com/@dr.ka....thleenruddy1734/vide

https://www.youtube.com/watch?v=m_78xfHRHUY

https://www.youtube.com/watch?v=jaY2BeNnfy8