What are turbo cancers? Part 1: IgG4 effect on immune cells

This is the first installment of a series dedicated to the molecular biology of unusual types of cancers called hyperprogressive disease that are colloquially referred to as “turbo cancers” (not a term used in medicine). In this episode, we provide the first ever published evidence of how IgG4 antibodies can play a role (in conjunction with other molecular events) in the development of turbo cancers.What we cover:*Turbo cancers exist in medicine but are called hyperprogressive disease*Turbo cancers appear to require 3 elements in the same environment: *cancer presence, *high IgG4 levels and *high glutathione levels*IgG4 immune checkpoint inhibitors used in cancer treatment*Hyperprogressive disease (turbo cancers) first described after the use of immune checkpoint inhibitors that were IgG4*Molecular understanding of how it happens only emerged in the last 5 years *Turbo cancers are still emerging knowledge as only a handful science papers published*2019 study of turbo cancer patients shows unique immune cell behaviour in cancers*2019 study of turbo cancers in mice provide genetic background predispositionLocation: Calgary, AlbertaDescribed content: https://aacrjournals.org/clinc....ancerres/article/25/


Credit: Dr. Raszek